CNS-CENTRAL & PERIPHERAL NERVOUS SYSTEM DISEASES
|
?Indication |
?Model |
?Species |
|
?Alzheimer's disease |
?APP/PS1 Mice |
?mice |
|
?5XFAD Mice |
?mice |
|
|
?Parkinson's disease |
?6-OHDA-induced PD |
?rat |
|
?MPTP-induced PD |
?monkey |
|
|
?Depression/Anxiety |
?Forced swimming? |
?rat, mice |
|
?Dangling tail |
?mice |
|
|
?Open field |
?rat, mice |
|
|
?Rlevated pluWs maze, EPM |
?rat, mice |
|
|
?m-CPP-induced anxiety-like symptoms |
?rat |
|
|
?Chronic unpredictable mild stress (CUMS) |
?mice |
|
|
?Learned helplessness |
?rat, mice |
|
|
?Epilepsy |
?PTZ-induced acute and chronic attacks |
?rat |
|
?monkey |
||
|
?Sleep/Sedation/Anesthesia Induction |
?Loss of righting reflex, LORR |
?rat, mice |
|
?Spontaneous activity level |
?rat, mice |
|
|
?Sedation rating |
?dog, swine, monkey |
|
|
?EEG telemetry |
?rat, mice |
|
|
?monkey |
||
|
?Pain |
?Acute gouty arthritis |
?rat, mice, UOX mice |
|
?Adjuvant arthritis |
?rat, mice |
|
|
?CIA arthritis |
?rat, mice |
|
|
?monkey |
||
|
?Carrageenan-induced plantar swelling |
?rat |
|
|
?Formalin causedkey pain |
?mice |
|
|
?Acetic acid writhing |
?mice |
|
|
?Nerve block |
?rat |
|
|
?Postoperative incision pain |
?rat |
|
|
?dog |
||
|
?Chronic neuralgia (CCI, SNI, SNL) |
?rat |
|
|
?Diabetic nerve pain |
?mice |
|
|
?Cancer pain ?Chemotherapy pain |
?mice |
|
|
?rat |
||
|
?Trigeminal neuralgia |
?rat |
|
|
?MIA osteoarthritis |
?rat |
|
|
?ACLT Osteoarthritis |
?dog |
|
|
?Stroke |
?Permanent ischemic MCAO |
?rat |
|
?Ischemia-reperfusion MCAO |
?rat |
|
|
?monkey |
||
|
?Spinal Cord Injury (SCI) |
?Spinal cord hemisection |
?rat, monkey |
|
?Spinal cord blow injury |
?rat, monkey |
|
|
?Drug dependence |
?Natural withdrawal |
?rat, mice |
|
?Urge withdrawal? |
?rat, mice |
|
|
?Conditioned Place Preference, CPP |
?rat |
|
|
?Self-administration |
?rat |
|
|
?Drug identification |
?rat |
|
|
?Migraine |
?Capsaicin-induced vasodilation model |
?rat |
|
?monkey |
||
|
?Somatic neurotoxicity |
?Polio, herpes, measles, mumps, rubella, etc. |
?monkey |
